Donatussin DM Suspension

Pronunciation: FEN-il-EF-rin/DEX-klor-fen-IR-a-meen/DEX-troe-meth-OR-fan
Generic Name: Phenylephrine/Dexchlorpheniramine/Dextromethorphan
Brand Name: Donatussin DM

Donatussin DM Suspension is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, itchy nose or throat, itchy or watery eyes, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Donatussin DM Suspension is a decongestant, antihistamine, and cough suppressant combination. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Donatussin DM Suspension if:

• you are allergic to any ingredient in Donatussin DM Suspension


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you are unable to urinate or are having an asthma attack


• you take droxidopa, sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Donatussin DM Suspension:

Some medical conditions may interact with Donatussin DM Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems (eg, fast, slow, or irregular heartbeat; heart disease), high or low blood pressure, diabetes, blood vessel problems, stroke, glaucoma or increased pressure in the eye, or thyroid problems


• if you have a history of asthma, chronic cough, lung or breathing problems (eg, chronic bronchitis, emphysema, sleep apnea), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus


• if you have a history of stomach or bowel pulcers; a blockage of your stomach, bladder, or intestines; kidney problems; or trouble urinating; or if you have an enlarged prostate or other prostate problems

• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, linezolid, MAOIs (eg, phenelzine), selective serotonin reuptake inhibitors (SSRIs) (eg, citalopram, fluoxetine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Donatussin DM Suspension's side effects


• Bromocriptine or hydantoins (eg, phenytoin) because the risk of their side effects may be increased by Donatussin DM Suspension


• Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Donatussin DM Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Donatussin DM Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Donatussin DM Suspension:

• Take Donatussin DM Suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• Shake well before each use.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Donatussin DM Suspension and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Donatussin DM Suspension.

Important safety information:

• Donatussin DM Suspension may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Donatussin DM Suspension with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Donatussin DM Suspension; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Do not take diet or appetite control medicines while you are taking Donatussin DM Suspension without checking with your doctor.


• Before you start any new medicine, check the label to see if it has a decongestant, antihistamine, or cough suppressant in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Do not use Donatussin DM Suspension for a cough with a lot of mucus. Do not use it for a long-term cough (eg, caused by asthma, emphysema, smoking). However, you may use it for these conditions if your doctor tells you to.


• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.


• Donatussin DM Suspension may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Donatussin DM Suspension. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.


• Donatussin DM Suspension may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Donatussin DM Suspension for a few days before the tests.


• Tell your doctor or dentist that you take Donatussin DM Suspension before you receive any medical or dental care, emergency care, or surgery.


• Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.


• Use Donatussin DM Suspension with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion, dizziness, drowsiness, dry mouth, nervouseness, sleeplessness, and trouble urinating.


• Caution is advised when using Donatussin DM Suspension in CHILDREN; they may be more sensitive to its effects, especially excitability.


• Donatussin DM Suspension should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Donatussin DM Suspension while you are pregnant. Some ingredients of Donatussin DM Suspension are found in breast milk. Do not breast-feed while taking Donatussin DM Suspension.

Possible side effects of Donatussin DM Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; loss of coordination; mental or mood changes (eg, depression); seizures; severe dizziness, drowsiness, lightheadedness, or headache; severe dryness of mouth, nose, and throat; severe or persistent trouble sleeping; shortness of breath; tremor; unusual bruising or bleeding; unusual tiredness or weakness; vision problems (eg, double vision, severe or persistent blurred vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; flushing; hallucinations; mental or mood changes; muscle spasms; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; trouble breathing; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Donatussin DM Suspension:

Store Donatussin DM Suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat and light. Keep Donatussin DM Suspension out of the reach of children and away from pets.

General information:

• If you have any questions about Donatussin DM Suspension, please talk with your doctor, pharmacist, or other health care provider.


• Donatussin DM Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Donatussin DM Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Donatussin DM resources

• Donatussin DM Use in Pregnancy & Breastfeeding
• Donatussin DM Drug Interactions
• Donatussin DM Support Group
• 0 Reviews for Donatussin DM - Add your own review/rating

Compare Donatussin DM with other medications

• Cough and Nasal Congestion

dornase alfa Inhalation, oral/nebulization

DOR-nase AL-fa

Commonly used brand name(s)

In the U.S.

• Pulmozyme

Available Dosage Forms:

• Solution

Therapeutic Class: Mucolytic

Pharmacologic Class: Mucolytic Enzyme

Uses For dornase alfa

Dornase alfa is used in the management of cystic fibrosis. It is used every day with other cystic fibrosis medicines, especially antibiotics, bronchodilators (medicines that open up narrowed breathing passages), and corticosteroids (cortisone-like medicines).

Cystic fibrosis is a condition in which thick mucus is formed in the lungs and breathing passages. The mucus blocks the airways and increases the chance of lung infections. The infections then cause the mucus to become even thicker, making it more difficult to breathe.

Dornase alfa will not cure cystic fibrosis. However, when it is used every day, it helps make breathing easier and reduces the number of serious lung infections that require treatment with antibiotics.

Dornase alfa is available only with your doctor's prescription.

Before Using dornase alfa

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dornase alfa, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to dornase alfa or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Dornase alfa has been studied in children 3 months of age and older and has not been shown to cause different side effects or problems in children than it does in adults, although coughing, runny or stuffy nose, and skin rashes were more common in children 3 months to 5 years of age than in other age groups.

Geriatric

Dornase alfa has not been tested on enough patients 65 years and older. Cystic fibrosis is a disease that usually affects children and young adults. Although there is no specific information comparing use of dornase alfa in the elderly with use in other age groups, dornase alfa is not expected to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of dornase alfa

Dornase alfa usually comes with patient instructions. Read them carefully before using dornase alfa.

Dornase alfa is packaged in small plastic containers called ampules. Each ampule contains one full dose of dornase alfa. Do not use an ampule that has already been opened. Also, do not use an ampule of dornase alfa after the expiration date printed on the package.

Do not use dornase alfa solution if it is cloudy or discolored.

Dornase alfa must be used in a nebulizer with a compressor . Only the following nebulizers and compressors should be used with dornase alfa:

• Hudson T Up-draft II disposable jet nebulizer used with the Pulmo-Aide compressor


• Marquest Acorn II disposable jet nebulizer used with the Pulmo-Aide compressor


• Reusable PARI LC Jet+ nebulizer used with the PARI PRONEB compressor


• Reusable PARI BABY nebulizer used with the PARI PRONEB compressor


• Reusable Durable Sidestream jet nebulizer with the MOBILAIRE or the Porta-Neb compressor

Your health care professional will help you decide which nebulizer and compressor to use.

It is very important that you use dornase alfa only as directed. Use the mouthpiece provided with the nebulizer. Do not use a face mask with the nebulizer because less medicine will get into your lungs. Patients who are unable to inhale and exhale through the mouth for the entire nebulizer treatment may use the PARI BABY nebulizer with the supplied face mask. Make sure you understand exactly how to use dornase alfa in the nebulizer.

In order to receive the full effects of dornase alfa, you must use it every day as ordered by your doctor. If possible, dornase alfa should be used at about the same time each day. You may notice some improvement in your condition within the first week of treatment. However, some patients may not feel the full effects of dornase alfa for weeks or months.

If you are taking any other medicines for cystic fibrosis, keep taking them as you did before you started using dornase alfa, unless otherwise directed by your doctor. However, do not put any other inhaled medicine in the nebulizer at the same time that you use dornase alfa. Other inhaled medicines may be used in a clean nebulizer before or after your treatment with dornase alfa.

To prepare the nebulizer for use:

• Wash your hands well with soap and water before putting the nebulizer together and preparing the medicine. This will help prevent infection.


• Put the nebulizer together only on a clean surface. If dirt or germs get on the nebulizer or in the medicine, they may cause infection.


• After you put the nebulizer together, test the compressor (following the manufacturer's directions) to make sure it works properly. If you have any questions about this, ask your health care professional.


• If you are using the Durable Sidestream jet nebulizer with the MOBILAIRE compressor, turn the compressor control knob all the way to the right and then turn on the compressor. The needle on the gauge vibrates between 35 and 45, which is the highest amount of pressure.

To prepare the medicine for use in the nebulizer:

• Remove one ampule of dornase alfa from the refrigerator. Squeeze the ampule before opening to make sure there are no leaks. Hold the tab at the base of the ampule firmly. Twist off the top of the ampule, but do not squeeze the body of the ampule while doing so.


• Take the cap off the nebulizer cup. Turn the opened ampule upside down over the cup. Squeeze the ampule gently until all the contents are emptied into the cup. It is very important that you use the full dose of dornase alfa.


• Replace the cap on the nebulizer cup. Connect the nebulizer and compressor, following the manufacturer's directions.


• Turn on the compressor. Make sure there is mist coming from the nebulizer.

To use the medicine in the nebulizer:

• Place the mouthpiece between your teeth and on top of your tongue. Close your lips around the mouthpiece. Be sure that you do not block the air flow with your tongue or teeth.


• Breathe normally, in and out, through your mouth. Do not breathe through your nose. If you have trouble breathing only through your mouth, use a nose clip.


• During treatment, moisture may collect in the long connecting tube of the nebulizer. This should be expected. However, if you notice a leak or feel moisture coming from the nebulizer during the treatment, turn off the compressor. Then check to make sure the nebulizer cap is sealed correctly before you continue the treatment.


• When the nebulizer begins 'spitting' gently tap the nebulizer cup. Continue breathing until the cup is empty or no more mist comes from the nebulizer.


• If you have to stop the treatment for some reason or if you start coughing during the treatment, turn off the compressor. To begin the treatment again, turn on the compressor and continue as before.


• The complete treatment usually takes 10 to 15 minutes. Be sure to inhale the full dose of dornase alfa.

After using dornase alfa:

• Turn off the compressor. Then take apart the nebulizer system.


• Follow the manufacturer's directions for care and cleaning of your nebulizer and compressor.

Dosing

The dose of dornase alfa will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dornase alfa. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For inhalation dosage form (inhalation solution):
  
  • For cystic fibrosis:
    
    • Adults and children 5 years of age and older—The usual dose is 2.5 milligrams (mg) (one ampule), used in a nebulizer once a day for about 10 to 15 minutes. However, your doctor may want you to use dornase alfa two times a day at regularly spaced times.
    
    
    • Children 3 months to 5 years of age—The usual dose is 2.5 milligrams (mg) (one ampule), used in a nebulizer once a day for about 10 to 15 minutes.
    
    
    • Children up to 3 months of age—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of dornase alfa, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store the medicine in the refrigerator in the foil pouches. However, keep the medicine from freezing. Do not leave dornase alfa out of the refrigerator for longer than 24 hours. If an ampule of medicine is left out for longer than this, it should be thrown away and a new ampule should be used.

Precautions While Using dornase alfa

If your condition becomes worse while you are using dornase alfa, check with your doctor.

dornase alfa Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

• Hives or welts


• itching


• redness of skin


• skin rash

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Chest pain or discomfort


• hoarseness


• sore throat

Less common

• Difficulty breathing


• fever


• redness, itching, pain, swelling, or other irritation of eyes


• runny or stuffy nose


• upset stomach

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: dornase alfa Inhalation,/nebulization side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More dornase alfa Inhalation, oral/nebulization resources

• Dornase alfa Inhalation, oral/nebulization Side Effects (in more detail)
• Dornase alfa Inhalation, oral/nebulization Use in Pregnancy & Breastfeeding
• Dornase alfa Inhalation, oral/nebulization Drug Interactions
• Dornase alfa Inhalation, oral/nebulization Support Group
• 0 Reviews for Dornase alfa Inhalation,/nebulization - Add your own review/rating

Compare dornase alfa Inhalation, oral/nebulization with other medications

• Cystic Fibrosis

Dolorex Forte

Generic Name: acetaminophen and hydrocodone (a SEET a MIN oh fen and hye droe KOE done)

Brand Names: Anexsia, Co-Gesic, Hycet, Liquicet, Lorcet 10/650, Lorcet Plus, Lortab 10/500, Lortab 2.5/500, Lortab 5/500, Lortab 7.5/500, Lortab Elixir, Maxidone, Norco, Polygesic, Stagesic, Vicodin, Vicodin ES, Vicodin HP, Xodol, Zamicet, Zolvit, Zydone

What is Dolorex Forte (acetaminophen and hydrocodone)?

Hydrocodone is in a group of drugs called narcotic pain relievers.

Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

The combination of acetaminophen and hydrocodone is used to relieve moderate to severe pain.

Acetaminophen and hydrocodone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Dolorex Forte (acetaminophen and hydrocodone)?

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

What should I discuss with my healthcare provider before taking Dolorex Forte (acetaminophen and hydrocodone)?

Do not use this medication if you are allergic to acetaminophen (Tylenol) or hydrocodone. Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take medicine that contains acetaminophen.

To make sure you can safely take acetaminophen and hydrocodone, tell your doctor if you have any of these other conditions:

• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• 
  

  liver or kidney disease;

  
  


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  a stomach or intestinal disorder;

  
  


• 
  

  underactive thyroid;

  
  


• 
  

  Addison's disease or other adrenal gland disorder;

  
  


• 
  

  curvature of the spine;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

Hydrocodone may be habit forming and should be used only by the person it was prescribed for. Never share acetaminophen and hydrocodone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby, but it could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Acetaminophen and hydrocodone can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Dolorex Forte (acetaminophen and hydrocodone)?

Take exactly as prescribed. Never take acetaminophen and hydrocodone in larger amounts, or for longer than recommended by your doctor. An overdose of acetaminophen can damage your liver or cause death.

One acetaminophen and hydrocodone tablet may contain up to 750 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking acetaminophen and hydrocodone. Ask your doctor about ways to increase the fiber in your diet. Do not use a stool softener (laxative) without first asking your doctor. Do not stop using this medicine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using acetaminophen and hydrocodone.

Acetaminophen can cause false results with certain lab tests for glucose (sugar) in the urine. Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

If you need surgery, tell the surgeon ahead of time that you are using acetaminophen and hydrocodone. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

What happens if I miss a dose?

Since acetaminophen and hydrocodone is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and hydrocodone can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include extreme drowsiness, pinpoint pupils, cold and clammy skin, muscle weakness, fainting, weak pulse, slow heart rate, coma, blue lips, shallow breathing, or no breathing

What should I avoid while taking Dolorex Forte (acetaminophen and hydrocodone)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Dolorex Forte (acetaminophen and hydrocodone) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  shallow breathing, slow heartbeat;

  
  


• 
  

  feeling light-headed, fainting;

  
  


• 
  

  confusion, fear, unusual thoughts or behavior;

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  problems with urination; or

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  anxiety, dizziness, drowsiness;

  
  


• 
  

  mild nausea, vomiting, upset stomach, constipation;

  
  


• 
  

  headache, mood changes;

  
  


• 
  

  blurred vision;

  
  


• 
  

  ringing in your ears; or

  
  


• 
  

  dry mouth.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Dolorex Forte (acetaminophen and hydrocodone)?

Do not take acetaminophen and hydrocodone with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Tell your doctor about all other medicines you use, especially:

• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan), nortriptyline (Pamelor), and others;

  
  


• 
  

  an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate);

  
  


• 
  

  atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), glycopyrrolate (Robinul), mepenzolate (Cantil), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  
  


• 
  

  a bronchodilator such as ipratropium (Atrovent) or tiotropium (Spiriva); or

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

  
  

This list is not complete and other drugs may interact with acetaminophen and hydrocodone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Dolorex Forte resources

• Dolorex Forte Side Effects (in more detail)
• Dolorex Forte Use in Pregnancy & Breastfeeding
• Drug Images
• Dolorex Forte Drug Interactions
• Dolorex Forte Support Group
• 370 Reviews for Dolorex Forte - Add your own review/rating

• Dolorex Forte Advanced Consumer (Micromedex) - Includes Dosage Information


• Co-gesic Prescribing Information (FDA)


• Dolacet MedFacts Consumer Leaflet (Wolters Kluwer)


• Hycet Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Hycet Prescribing Information (FDA)


• Liquicet Prescribing Information (FDA)


• Lorcet Plus Prescribing Information (FDA)


• Lortab Consumer Overview


• Lortab MedFacts Consumer Leaflet (Wolters Kluwer)


• Lortab Prescribing Information (FDA)


• Maxidone Prescribing Information (FDA)


• Norco Prescribing Information (FDA)


• Norco Consumer Overview


• Vicodin Prescribing Information (FDA)


• Vicodin Consumer Overview


• Vicodin ES Prescribing Information (FDA)


• Vicodin HP Prescribing Information (FDA)


• Xodol Prescribing Information (FDA)


• Zolvit Prescribing Information (FDA)


• Zydone Prescribing Information (FDA)

Compare Dolorex Forte with other medications

• Back Pain
• Cough
• Pain
• Rheumatoid Arthritis

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and hydrocodone.

See also: Dolorex Forte side effects (in more detail)

Donor Prep Kit

Dosage Form: preoperative skin preparation
Donor Prep Kit Drug Facts

Active ingredient

Frepp

Isopropyl alcohol 70% v/v USP

Sepp

Iodine 2% w/v USP

Purpose

Antiseptic

Uses

Frepp

• for the preparation of the patient's skin prior to injection

Sepp

• patient preoperative skin preparation: Helps to reduce bacteria that potentially can cause skin infection

Warnings

For external use only

Flammable: Keep away from fire or flame

Do not use with electrocautery procedures

Do not use

Frepp

on patients with known allergies to isopropyl alcohol

Sepp

on patients with known allergies to ethyl alcohol or iodine

When using this product

keep out of eyes, ears, and mouth

Stop use and ask a doctor if

irritation, sensitization, allergic reaction, or other side effects occur. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions

Frepp

• locate the vein to be used


• remove Frepp from kit. Hold in a horizontal position and pinch handle once to break ampule. Do not continue to squeeze handle.


• place sponge on selected venipuncture site and depress once or twice to saturate sponge


• scrub vigorously for at least 30 seconds


• allow to dry

Sepp

• remove Sepp. Hold in downward position and pinch center of Sepp to crush ampule.


• use repeated back-and-forth strokes of the applicator for approximately 30 seconds or apply iodine tincture to venipuncture site starting at center and moving outward in concentric circles to periphery. Allow to dry.


• proceed with collection of blood


• discard unused components

Other information

 

store below 30 °C (86 °F)

Inactive ingredients

Frepp

• USP purified water

Sepp

• USP purified water


• ethyl alcohol


• sodium iodide USP

Questions?

Call 1-800-523-0502 (M-F 8 a.m.-5 p.m. CST)

Package/Label Principal Display Panel

Donor Prep Kit Carton

Donor Prep Kit

NDC 54365-201-99

Single Use

Latex Free

Contents STERILE if primary package is intact

20 Kits

Each kit contains:

1 FREPP - isopropyl alcohol

Net 1.1 ml

1 SEPP - iodine tincture 2% USP

Net 0.67 ml

Donor Prep Kit

CareFusion

Leawood, KS 66211

1.800.523.0502

Made in

Store below 30 °C or 86 °F

For external use only

For hospital and professional use only

Donor Prep Kit  isopropyl alcohol and iodine  kit

Product Information Product Type HUMAN OTC DRUG NDC Product Code (Source) 54365-201

Packaging # NDC Package Description Multilevel Packaging 1 54365-201-99 1 KIT In 1 POUCH None

QUANTITY OF PARTS Part # Package Quantity Total Product Quantity Part 1 1 APPLICATOR   1.1 mL Part 2 1 AMPULE   0.67 mL

Part 1 of 2 FREPP  isopropyl alcohol  solution

Product Information NDC Product Code (Source) 54365-170     Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength ISOPROPYL ALCOHOL (ISOPROPYL ALCOHOL) ISOPROPYL ALCOHOL 0.7 mL  in 1 mL

Inactive Ingredients Ingredient Name Strength WATER

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 54365-170-02 1.1 mL In 1 APPLICATOR None

Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date OTC monograph not final part333A 02/01/1988

Part 2 of 2 SEPP  iodine  tincture

Product Information NDC Product Code (Source) 54365-161     Route of Administration TOPICAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength IODINE (IODINE) IODINE 20 mg  in 1 mL

Inactive Ingredients Ingredient Name Strength SODIUM IODIDE   ALCOHOL   WATER

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 54365-161-01 0.67 mL In 1 AMPULE None

Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date OTC monograph not final part333A 02/01/1988

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
OTC monograph not final	part333A	02/01/1988

Labeler - CareFusion 213 LLC (831684456)

Establishment
Name	Address	ID/FEI	Operations
CareFusion 213 LLC		830430810	ANALYSIS, LABEL, MANUFACTURE, PACK

Revised: 05/2010CareFusion 213 LLC

Dolono

Generic Name: acetaminophen (Oral route, Rectal route)

a-seet-a-MIN-oh-fen

Commonly used brand name(s)

In the U.S.

• Actamin Maximum Strength


• Altenol


• Aminofen


• Anacin Aspirin Free


• Apra


• Cetafen


• Children's Nortemp


• Comtrex Sore Throat Relief


• Dolono


• Feverall


• Genapap


• Tylenol

In Canada

• Abenol


• Acetaminophen


• Actimol Children's


• Actimol Infant


• Atasol


• Children's Acetaminophen


• Children's Acetaminophen Bubble Gum Flavor


• Children's Acetaminophen Cherry Flavor


• Children's Acetaminophen Grape Flavor


• Children's Acetaminophen Suspension Bubble Gum Flavor - Ages 2 To 11


• Children's Acetaminophen Suspension Cherry Flavor


• Children's Acetaminophen Suspension Grape Flavor - Ages 2 To 11

Available Dosage Forms:

• Solution


• Tablet, Disintegrating


• Suppository


• Powder


• Syrup


• Tablet


• Tablet, Chewable


• Capsule


• Powder for Solution


• Suspension


• Elixir


• Tablet, Extended Release


• Capsule, Liquid Filled


• Liquid


• Tablet, Effervescent

Therapeutic Class: Analgesic

Uses For Dolono

Acetaminophen is used to relieve minor aches and pain and reduce fever. Unlike aspirin, it does not relieve the redness, stiffness, or swelling caused by rheumatoid arthritis. However, it may relieve the pain caused by mild forms of arthritis.

This medicine is available without a prescription.

Before Using Dolono

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of acetaminophen in children. However, do not administer the over-the-counter products to children under 2 years old unless your doctor has instructed you to do so.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of acetaminophen in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acenocoumarol


• Carbamazepine


• Isoniazid


• Phenytoin


• Warfarin


• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Cabbage

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse, or history of or


• Kidney disease, severe or


• Liver disease (including hepatitis)—The chance of serious side effects may be increased.

• Phenylketonuria (PKU)—Some brands of acetaminophen contain aspartame, which can make your condition worse.

Proper Use of acetaminophen

This section provides information on the proper use of a number of products that contain acetaminophen. It may not be specific to Dolono. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may cause an overdosage. Liver damage can occur if large amounts of acetaminophen are taken for a long time.

Carefully check the labels of all other medicines you are using, because they may also contain acetaminophen. It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours).

You may take this medicine with or without food.

If you are taking this medicine without the advice of your doctor, carefully read and follow the drug facts label and dosing instructions on the medicine package. This is to avoid confusion and dosing errors. Ask your doctor if you have any questions.

For patients using the oral liquid with syringe (e.g. Little Fevers®):

• Shake the bottle well before each use.


• Measure the dose with the provided dose syringe (e.g., AccuSafe™) that comes with the package. Do not use any other syringe, dropper, spoon, or dosing device when giving this medicine to your child.


• Remove the cap, attach the syringe to the flow restrictor, and invert the bottle.


• Pull back the syringe until filled with the dose prescribed by your doctor.


• Slowly give the medicine into your child's mouth (towards the inner cheek).


• Replace the cap back tightly.

For patients using the oral liquid with dropper:

• Shake the bottle well before each use.


• Measure the dose with the provided dropper. Do not use any other syringe, dropper, spoon, or dosing device when giving this medicine to your child.


• Remove the cap, insert the dropper and withdraw the dose prescribed by your doctor.


• Slowly give the medicine into your child's mouth (towards the inner cheek).


• Replace the cap back tightly.

For patients using acetaminophen oral granules (e.g., Snaplets-FR):

• Just before the medicine is to be taken, open the number of packets needed for one dose.


• Mix the granules inside of the packets with a small amount of soft food, such as applesauce, ice cream, or jam.


• Eat the acetaminophen granules along with the food.

For patients using acetaminophen oral powders (e.g., Feverall® Sprinkle Caps [Children's or Junior Strength]):

• These capsules are not intended to be swallowed whole. Instead, just before the medicine is to be taken, open the number of capsules needed for one dose.


• Empty the powder from each capsule into 1 teaspoonful (5 mL) of water or other liquid.


• Drink the medicine along with the liquid. You may drink more liquid after taking the medicine.


• You may also mix the powder with a small amount of soft food, such as applesauce, ice cream, or jam. Eat the acetaminophen powder along with the food.

For patients using acetaminophen suppositories:

• If the suppository is too soft to insert, chill it in the refrigerator for 30 minutes or run cold water over it before removing the foil wrapper.


• To insert the suppository:
  
  • First remove the foil wrapper and moisten the suppository with cold water.
  
  
  • Lie down on your side and use your finger to push the suppository well up into the rectum.
  
  

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For pain or fever:
  
  • For oral dosage forms (capsules, granules, powders, solution, suspension, or tablets) and rectal dosage forms (suppositories):
    
    • Adults and teenagers—325 or 500 milligrams (mg) every 3 or 4 hours, 650 mg every 4 to 6 hours, or 1000 mg every 6 hours as needed. The total dose should not be more than 4000 mg (for example, eight 500–mg tablets) a day.
    
    
    • Children—Dose is based on the child's age, do not administer the over-the-counter products to children under the age of 2 unless directed to do so by your doctor:
      
      • Children 11 to 12 years of age: 320 to 480 mg every 4 hours as needed.
      
      
      • Children 9 to 11 years of age: 320 to 400 mg every 4 hours as needed.
      
      
      • Children 6 to 9 years of age: 320 mg every 4 hours as needed.
      
      
      • Children 4 to 6 years of age: 240 mg every 4 hours as needed.
      
      
      • Children 2 to 4 years of age: 160 mg every 4 hours as needed.
      
      
      • Children 1 to 2 years of age: 120 mg every 4 hours as needed.
      
      
      • Infants 4 to 12 months of age: 80 mg every 4 hours as needed.
      
      
      • Infants up to 3 months of age: 40 mg every 4 hours as needed.
      
      
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep the bottle closed when you are not using it. Store it at room temperature, away from light and heat. Do not freeze.

You may store the suppositories in the refrigerator, but do not freeze them.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Dolono

It is very important that your doctor check the progress of you or your child while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you or your child should continue to take it.

If your symptoms do not improve within a few days or if they become worse, check with your doctor.

Stop using this medicine and check with your doctor or dentist right away:

• If you are taking this medicine to relieve pain, including arthritis pain, and the pain lasts for more than 10 days for adults or 5 days for children or if the pain gets worse, new symptoms occur, or the painful area is red or swollen. These could be signs of a serious condition that needs medical or dental treatment.


• If you are taking this medicine to bring down a fever, and the fever lasts for more than 3 days or returns, the fever gets worse, new symptoms occur, or redness or swelling is present. These could be signs of a serious condition that needs treatment.


• If you are taking this medicine for a sore throat, and the sore throat is very painful, lasts for more than 2 days, or occurs together with or is followed by fever, headache, skin rash, nausea, or vomiting.

Many combination medicines contain acetaminophen, including products with brand names such as Alka-Seltzer Plus®, Comtrex®, Drixoral®, Excedrin Migraine®, Midol®, Sinutab®, Sudafed®, Theraflu®, and Vanquish®. Adding these medicines to the medicine that you are already taking may cause you to get more than a safe amount of acetaminophen. Talk to your doctor before taking more than one medicine that contains acetaminophen.

Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.

If you will be taking more than an occasional 1 or 2 doses of acetaminophen, do not drink alcoholic beverages. To do so may increase the chance of liver damage, especially if you drink large amounts of alcoholic beverages regularly, if you take more acetaminophen than is recommended on the package label, or if you take it regularly for a long time.

Taking certain other medicines together with acetaminophen may increase the chance of unwanted effects. The risk will depend on how much of each medicine you take every day, and on how long you take the medicines together. If your doctor or dentist directs you to take these medicines together on a regular basis, follow his or her directions carefully. However, do not take any of the following medicines together with acetaminophen for more than a few days unless your doctor has directed you to do so and is following your progress:

• Aspirin or other salicylates


• Diclofenac (e.g., Voltaren®)


• Diflunisal (e.g., Dolobid®)


• Etodolac (e.g., Lodine®)


• Fenoprofen (e.g., Nalfon®)


• Floctafenine (e.g., Idarac®)


• Flurbiprofen, oral (e.g., Ansaid®)


• Ibuprofen (e.g., Motrin®)


• Indomethacin (e.g., Indocin®)


• Ketoprofen (e.g., Orudis®)


• Ketorolac (e.g., Toradol®)


• Meclofenamate (e.g., Meclomen®)


• Mefenamic acid (e.g., Ponstel®)


• Nabumetone (e.g., Relafen®)


• Naproxen (e.g., Naprosyn®)


• Oxaprozin (e.g., Daypro®)


• Phenylbutazone (e.g., Butazolidin®)


• Piroxicam (e.g., Feldene®)


• Sulindac (e.g., Clinoril®)


• Tenoxicam (e.g., Apo-Tenoxicam®)


• Tiaprofenic acid (e.g., Surgam®)


• Tolmetin (e.g., Tolectin®).

Acetaminophen may interfere with the results of some medical tests. Before you have any medical tests, tell the person in charge if you have taken acetaminophen within the past 3 or 4 days. If possible, it is best to call the laboratory where the test will be done about 4 days ahead of time, to find out whether this medicine may be taken during the 3 or 4 days before the test.

For diabetic patients:

• Acetaminophen may cause false results with some blood glucose (sugar) tests. If you notice any change in your test results, or if you have any questions about this possible problem, check with your doctor. This is especially important if your diabetes is not well-controlled.

For patients taking one of the products that contain caffeine in addition to acetaminophen:

• Caffeine may interfere with the results of a test that uses adenosine (e.g., Adenocard®) or dipyridamole (e.g., Persantine®) to help find out how well your blood is flowing through certain blood vessels. Therefore, you should not have any caffeine for 8 to 12 hours before the test.

If you think that you or anyone else may have taken an overdose of acetaminophen, get emergency help at once, even if there are no signs of poisoning. Signs of severe poisoning may not appear for 2 to 4 days after the overdose is taken, but treatment to prevent liver damage or death must be started as soon as possible. Treatment started more than 24 hours after the overdose is taken may not be effective.

Dolono Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Bloody or black, tarry stools


• bloody or cloudy urine


• fever with or without chills (not present before treatment and not caused by the condition being treated)


• pain in the lower back and/or side (severe and/or sharp)


• pinpoint red spots on the skin


• skin rash, hives, or itching


• sore throat (not present before treatment and not caused by the condition being treated)


• sores, ulcers, or white spots on the lips or in the mouth


• sudden decrease in the amount of urine


• unusual bleeding or bruising


• unusual tiredness or weakness


• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

• Diarrhea


• increased sweating


• loss of appetite


• nausea or vomiting


• stomach cramps or pain


• swelling, pain, or tenderness in the upper abdomen or stomach area

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Dolono side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Dolono resources

• Dolono Side Effects (in more detail)
• Dolono Use in Pregnancy & Breastfeeding
• Dolono Drug Interactions
• Dolono Support Group
• 0 Reviews for Dolono - Add your own review/rating

• Acetaminophen Monograph (AHFS DI)


• Acetaminophen MedFacts Consumer Leaflet (Wolters Kluwer)


• Acetazolamide Monograph (AHFS DI)


• Apraclonidine Hydrochloride Monograph (AHFS DI)


• Genapap Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)


• Mapap Suppositories MedFacts Consumer Leaflet (Wolters Kluwer)


• Ofirmev Prescribing Information (FDA)


• Ofirmev Injection MedFacts Consumer Leaflet (Wolters Kluwer)


• Ofirmev Consumer Overview


• Paracetamol Consumer Overview


• Tempra 1 Drops MedFacts Consumer Leaflet (Wolters Kluwer)


• Tylenol Consumer Overview


• Tylenol MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Dolono with other medications

• Fever
• Muscle Pain
• Pain
• Sciatica

Dolacet

Pronunciation: a-SEET-a-MIN-oh-fen/HYE-droe-KOE-done
Generic Name: Acetaminophen/Hydrocodone
Brand Name: Examples include Dolacet and Stagesic

Dolacet contains acetaminophen. Severe and sometimes fatal liver problems, including the need for liver transplant, have been reported with the use of acetaminophen. Most cases of these liver problems occurred in patients taking excessive doses of acetaminophen (more than 4,000 mg per day). Also, patients who developed these liver problems were often using more than 1 medicine that contained acetaminophen. Discuss any questions or concerns with your doctor.

Dolacet is used for:

Treating moderate to moderately severe pain. It may also be used for other conditions as determined by your doctor.

Dolacet is an analgesic combination. Acetaminophen works by lowering a chemical in the brain that stimulates pain nerves. Hydrocodone, an opioid (narcotic) analgesic, works by binding to receptors in the brain and nervous system used by the body's natural "pain relievers." The combination may provide better pain relief than either medicine alone.

Do NOT use Dolacet if:

• you are allergic to any ingredient in Dolacet


• you have diarrhea associated with poisoning, antibiotic use, or a bacterial infection (from eating or drinking contaminated food or water)


• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dolacet:

Some medical conditions may interact with Dolacet. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you are allergic to other narcotic medicines (eg, medicines that contain codeine, morphine, oxycodone)


• if you have or have ever had alcoholism, substance abuse, narcotic dependence, or if you consume more than 3 alcoholic drinks per day


• if you have a history of suicidal thoughts or behavior


• if you have a head injury, increased pressure in the head, a brain injury or tumor, epilepsy, or seizures


• if you are having an asthma attack


• if you have an acute stomach or intestinal problem, chronic inflammation and ulceration of the bowel, or you have had recent abdominal surgery


• if you have adrenal gland problems; enlargement of the prostate gland; heart failure or lung disease, including shortness of breath; liver or kidney problems; thyroid disease; urinary blockage; or viral hepatitis

Some MEDICINES MAY INTERACT with Dolacet. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Barbiturate anesthetics (eg, thiopental), cimetidine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because serious side effects, such as increased sleepiness and decreased ability to breathe, may occur


• Naltrexone because it may decrease the effectiveness of Dolacet and withdrawal symptoms may occur in patients who have become physically dependent on opioids

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dolacet may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dolacet:

Use Dolacet as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Dolacet by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.


• If you miss a dose of Dolacet, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dolacet.

Important safety information:

• Dolacet may cause drowsiness, dizziness, blurred vision, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Dolacet with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Dolacet; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.


• Dolacet may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.


• Dolacet has acetaminophen in it. Before you start any new medicine, check the label to see if it has acetaminophen in it too. If it does or if you are not sure, check with your doctor or pharmacist.


• Dolacet may harm your liver. Your risk may be greater if you drink alcohol while you are using Dolacet. Talk to your doctor before you take Dolacet or other fever reducers if you drink more than 3 drinks with alcohol per day.


• Use Dolacet with caution in the ELDERLY; they may be more sensitive to its effects, especially possible decreased breathing and drowsiness.


• Dolacet should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Dolacet while you are pregnant. Dolacet is found in breast milk. Do not breast-feed while taking Dolacet.

When used for long periods of time or at high doses, Dolacet may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Dolacet stops working well. Do not take more than prescribed.

Some people who use Dolacet for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Dolacet, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Dolacet:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dizziness; drowsiness; flushing; light-headedness; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; change in the amount of urine produced; fear; hearing change or loss; interrupted breathing; mental or mood changes; unusual tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Dolacet side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish skin; cold/clammy skin; difficult or slow breathing; drowsiness leading to unresponsiveness or coma; excessive sweating; loss of function in the heart and lungs; nausea and vomiting; pinpoint pupils; seizure; stomach or intestinal pain.

Proper storage of Dolacet:

Store Dolacet at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not refrigerate. Do not freeze. Dispense in a tight, light-resistant container. Do not store in the bathroom. Keep Dolacet out of the reach of children and away from pets.

General information:

• If you have any questions about Dolacet, please talk with your doctor, pharmacist, or other health care provider.


• Dolacet is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Dolacet. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

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• Dolacet Drug Interactions
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dornase alfa inhalation

Generic Name: dornase alfa (inhalation) (DOOR nase AL fa)

Brand Names: Pulmozyme

What is dornase alfa?

Dornase alfa is a synthetic protein that breaks down excess DNA in the pulmonary secretions of people with cystic fibrosis.

Dornase alfa is used to improve lung function in people with cystic fibrosis by thinning pulmonary secretions and reducing the risk of respiratory tract infections.

Dornase alfa may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about dornase alfa?

Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.

Ampules of dornase alfa do not contain a preservative. Once opened, the entire contents of the ampule must be used or discarded.

Dornase alfa must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Dornase alfa should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours.

What should I discuss with my healthcare provider before using dornase alfa?

Do not use dornase alfa if you have had an allergic reaction to it or to other Chinese Hamster Ovary cell products.

Before using dornase alfa, tell your doctor if you have any other medical conditions or if you take other prescription or over-the-counter medicines. You may require a dosage adjustment or special monitoring during your treatment.

Dornase alfa is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether dornase alfa passes into breast milk. Do not use dornase alfa without first talking to your doctor if you are breast-feeding a baby.

How should I use dornase alfa?

Use dornase alfa exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Dornase alfa is administered by inhalation using a recommended nebulizer. Your doctor or other healthcare provider will give you detailed instructions on the use and maintenance of the nebulizer.

Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.

If you are also taking other respiratory medications, use them in the order directed by your doctor (e.g., a bronchodilator, followed by chest physiotherapy, then dornase alfa, etc.) Do not dilute or mix dornase alfa with other agents in the nebulizer at the same time.

Ampules of dornase alfa do not contain a preservative. It is intended for one-time use only. Once opened, the entire contents of the ampule must be used or discarded.

Do not use any dornase alfa solution that is cloudy or discolored. Throw away any unused dornase alfa on the expiration date stamped on the ampule.

Dornase alfa should be used on a regular basis to get the most benefit.

Dornase alfa must be stored in the refrigerator between 36 and 46 degrees Fahrenheit (2 and 8 degrees Celsius) and protected from strong light. Keep unused ampules in the protective foil pouch. Dornase alfa should be kept refrigerated during transport. Combined lengths of exposure of the medication to room temperature should not exceed 24 hours.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and use only the next regularly scheduled dose as directed. Do not use a double dose.

What happens if I overdose?

An overdose of dornase alfa is unlikely to threaten life. If an overdose is suspected, contact your doctor, a hospital emergency room, or a poison control center.

Symptoms of a dornase alfa overdose are not known.

What should I avoid while using dornase alfa?

Do not dilute or mix the dornase alfa solution with any other drugs in the nebulizer. Mixing of dornase alfa with other drugs could lead to changes in the actions of the medications.

Dornase alfa side effects

If you experience any of the following serious side effects while taking dornase alfa, seek emergency medical attention or contact your doctor immediately:

• 
  

  an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  
  


• 
  

  increased difficulty breathing;

  
  


• 
  

  chest pain; or

  
  


• 
  

  fever.

  
  

Less serious side effects may be more likely to occur with the use of dornase alfa. Talk to your doctor if you experience any of the following side effects:

• 
  

  voice alteration;

  
  


• 
  

  sore throat;

  
  


• 
  

  rash;

  
  


• 
  

  laryngitis;

  
  


• 
  

  eye redness, irritation, or inflammation; or

  
  


• 
  

  nasal stuffiness or discharge.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Dornase alfa Dosing Information

Usual Adult Dose for Cystic Fibrosis:

2.5 mg (1 ampule) inhaled once daily using a recommended nebulizer. Some patients may benefit from twice daily administration.

Usual Pediatric Dose for Cystic Fibrosis:

> 5 years: 2.5 mg (1 ampule) inhaled once daily using a recommended nebulizer. Some patients may benefit from twice daily administration.

What other drugs will affect dornase alfa?

There are no known interactions between dornase alfa and other medicines. Talk to your doctor or pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with dornase alfa.

More dornase alfa resources

• Dornase alfa Side Effects (in more detail)
• Dornase alfa Dosage
• Dornase alfa Use in Pregnancy & Breastfeeding
• Dornase alfa Drug Interactions
• Dornase alfa Support Group
• 0 Reviews for Dornase alfa - Add your own review/rating

Compare dornase alfa with other medications

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Where can I get more information?

• Your pharmacist has more information about dornase alfa written for health professionals that you may read.

See also: dornase alfa side effects (in more detail)